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Perivascular soft tissue tumors are uncommon neoplasms

April 14, 2019 0 Comment

Perivascular soft tissue tumors are uncommon neoplasms, and is mostly originated from pericytes that express angiopoietin-1 and -2 among the perivascular soft tissue tumors.

1. Angiopoietin -1 is composed by perivascular cells and pericytes along with endothelium that involves reciprocal communication between an endothelium and pericytes.

2. Angiopoietin -2 is expressed in the endothelium and pericytes, and it increases tumor vascularization and regulate angiogenesis.

3. Ang -1 expression is identify with the pericyte recruitment for vascularization and tumor growth and develop the expression of new vessels due to Tie-2 pericyte precursors.

4. Angiopoietin is significant in angiogenesis and vascularization through the Tie 2 pathway.

5. The distribution of Ang-1 and Ang-2 was examined by immunohistochemical staining along large and small blood vessels not related with tumors.

6. Ang -1 and Ang-2 expressed malignant glomus tumors in the perivascular soft tissue tumors.